KiNativ™ Applications

Determine relative & absolute KiNativ™ IC₅₀/K_d values to accurately assess off-target risks

• High correlation between KiNativ™ results and in vivo efficacy enables an elevated level of decision making compared to recombinant kinase assays
• Eliminate wasted efforts on false positives (both on- or off-target hits)

Generate SAR for all kinases found in your cellular or animal efficacy model

• Focus on the kinases that really matter in your system
• Directly correlate target binding with biological outcome to confirm mechanism of action

Ex vivo profiling of treated live
cells or tissues from treated animals

• Verify target engagement in tissue of interest (pharmacodynamic studies)
• Determine mechanism of action and/or toxicity
• Identify primary and secondary effects of compound treatment
• Discover clinical biomarkers from biopsy or blood samples